Most puppies that bite are exploring the world using their mouths and will interact with people in a playful way, which includes nipping and biting, and do not have rabies. However, all bites from unvaccinated animals living in regions where rabies is endemic should be investigated by a medical expert.
If the puppy has been restricted indoors, walked only on a leash outdoors, and the owner is confident that the puppy has not interacted with any wildlife or other dogs, then it is extremely unlikely that the puppy is infected with the rabies virus. A person bitten by an unvaccinated puppy that has been roaming outdoors or exposed to other animals may be at risk for the rabies virus and should seek medical advice. Even puppies that have been contained in a fenced-in backyard, may still have been exposed to high risk wildlife such as skunks, coyotes, fox, raccoons and bats, and a bite from an unvaccinated puppy is a considered a risk for contracting the disease if the puppy has not been in a restricted environment.